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    Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation


    Mujahid, Muhammad and Trendafilova, Natasha and Foltyn Arfa-Kia, Agnieszka and Rosair, Georgina and Kavanagh, Kevin and Devereux, Michael and Walsh, Maureen and McClean, Siobhan and Creaven, Bernadette S. and Georgieva, Ivelina (2016) Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation. Journal of Inorganic Biochemistry, 163. pp. 53-67. ISSN 0162-0134

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    Abstract

    Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts have been prepared and characterised by microanalytical data and spectroscopic techniques (IR, 1H, 13C NMR, UV–Vis). The crystal structure of one Ag(I) complex was determined by X-ray diffraction analysis. The experimental spectroscopic data have been interpreted on the basis of molecular structure modeling and subsequent spectra simulation with density functional theory method. The binding modes of the coumarins and phenanthroline ligands (monodentate, bidentate, bridging) to Ag(I) have been theoretically modelled and discussed as to the most probable ligand binding in the series of complexes studied. The antimicrobial and antifungal activities have been determined and the complexes were found to have mostly moderate antibacterial activity but some of the phenanthroline adducts were found to have antifungal activity against the clinically important fungus C. albicans, comparable to that of the commercial agents, Amphotericin B and Ketoconazole. Preliminary investigations into the possible mechanism of action of the silver complexes indicated that they did not interact with DNA via nuclease activity or intercalation but the ability to act as a superoxide dismutase mimetic may be related to their antimicrobial activity.

    Item Type: Article
    Keywords: Coumarin; Phenanthroline; Ag(I) complexes; DFT modeling; Biological activity; X-ray structure;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11083
    Identification Number: https://doi.org/10.1016/j.jinorgbio.2016.07.010
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 24 Sep 2019 13:26
    Journal or Publication Title: Journal of Inorganic Biochemistry
    Publisher: Elsevier
    Refereed: Yes
    URI:

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