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    Membrane changes associated with the early stages of apoptosis in HEp-2 cells decrease susceptibility to adherence by Candida albicans


    Cotter, Gary and Verhaegen, S. and Clynes, M. and Kavanagh, Kevin (1997) Membrane changes associated with the early stages of apoptosis in HEp-2 cells decrease susceptibility to adherence by Candida albicans. Journal of Medical and Veterinary Mycology, 35 (3). pp. 219-223. ISSN 0268-1218

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    Abstract

    The aim of the present work was to establish whether apoptotic HEp-2 cells demonstrated an altered susceptibility to adherence by the pathogenic yeast Candida albicans. Cultures of HEp-2 cells were treated with concentrations of three chemotherapeutic agents sufficient to induce cell death by apoptosis and this was confirmed by microscopic examination and by the loss of membrane asymmetry (as indicated by phosphatidylserine externalization) and the fragmentation of nuclear DNA into distinct subunits. Cells in the early stages of apoptosis demonstrated a reduced susceptibility to adherence by a number of strains of C. albicans. A correlation between the decrease in yeast adherence and the loss of membrane asymmetry, associated with the early stages of apoptosis, was established.

    Item Type: Article
    Additional Information: Cite as: G. Cotter, S. Verhaegen, M. Clynes, K. Kavanagh, Membrane changes associated with the early stages of apoptosis in HEp-2 cells decrease susceptibility to adherence by Candida albicans, Journal of Medical and Veterinary Mycology, Volume 35, Issue 3, May 1997, Pages 219–224, https://doi.org/10.1080/02681219780001171
    Keywords: adherence; apoptosis; Candida; HEp-2;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11121
    Identification Number: https://doi.org/10.1080/02681219780001171
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 03 Oct 2019 14:46
    Journal or Publication Title: Journal of Medical and Veterinary Mycology
    Publisher: ISHAM (International Society for Human and Animal Mycology)
    Refereed: Yes
    URI:

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