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    Adherence mechanisms of Candida albicans


    Cotter, Gary and Kavanagh, Kevin (2000) Adherence mechanisms of Candida albicans. British journal of biomedical science, 57 (3). pp. 241-249. ISSN 0967-4845

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    Abstract

    The yeast Candida albicans is an opportunistic fungal pathogen that is capable of inducing a range of superficial and systemic diseases in the immunocompromised host. Although it displays a variety of virulence factors, one--the ability to adhere to host tissue--is considered essential in the early stages of colonisation and tissue invasion. Adherence is achieved by a combination of specific (ligand-receptor interactions) and non-specific (electrostatic charge, van der Waals forces) mechanisms which allow the yeast to attach to a wide range of tissue types and inanimate surfaces. Conventional methods for treating disease cause by C. albicans rely upon the use of antifungal drugs designed to kill the yeast or arrest its growth. An alternative approach, aimed at disrupting the adherence of the yeast to host tissue in cases of superficial infection, may have potential for controlling disease, particularly in situations where the unattached fungal cell can be removed from the affected site, either by the flushing action of the oropharynx or by the production of mucus in the vagina.

    Item Type: Article
    Keywords: Adherence; Adhesins; Antifungal agents; Candida; Virulence;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11131
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 04 Oct 2019 16:07
    Journal or Publication Title: British journal of biomedical science
    Publisher: Royal Society of Medicine
    Refereed: Yes
    URI:

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