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    Insect and Mammalian Innate Immune Responses Are Much Alike


    Kavanagh, Kevin and Reeves, Emer P. (2007) Insect and Mammalian Innate Immune Responses Are Much Alike. Microbe, 2 (12). pp. 596-599. ISSN 1558-7460

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    Abstract

    The innate immune systems of mammals and insects have several features in common. Both insect hemocytes and mammalian neutrophils engulf and kill pathogens, and both types of cell produce superoxide, using extraordinarily similar p47 and p67 proteins. Larvae of the greater wax moth Galleria mellonella provide a model system for evaluating familiar bacterial and fungal pathogens as well as for testing candidate antimicrobials. Insect immune systems function cooperatively and exhibit both humoral and cellular components.

    Item Type: Article
    Keywords: Insect; Mammal; Innate Immune Responses;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11133
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 04 Oct 2019 16:23
    Journal or Publication Title: Microbe
    Publisher: American Society for Microbiology
    Refereed: Yes
    Funders: Higher Education Authority (HEA)
    URI:

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