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    Galleria mellonella larvae as models for studying fungal virulence


    Kavanagh, Kevin and Fallon, John P. (2010) Galleria mellonella larvae as models for studying fungal virulence. Fungal Biology Reviews, 24 (1-2). pp. 79-83. ISSN 1749-4613

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    Abstract

    As a result of the strong structural and functional similarities between the innate immune system of mammals and the insect immune response, insects have been exploited for evaluating the virulence of fungal pathogens of humans and for assessing the efficacy of anti-fungal agents. There is a strong correlation between the results obtained using insects and mammals and insects have the added advantage of being cheap to purchase, give results in 24–48 h and are without the ethical and legal restrictions associated with the use of mammals. Larvae of Galleria mellonella are excellent in vivo models and have been used with a variety of fungi and anti-fungal agents. Factors affecting the use of G. mellonella larvae are described and examples of where these larvae have been utilized are discussed.

    Item Type: Article
    Keywords: Alternative models; Aspergillus; Candida; Fungi; Galleria mellonella; In vivo testing; Mini-hosts;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11148
    Identification Number: https://doi.org/10.1016/j.fbr.2010.04.001
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 08 Oct 2019 13:23
    Journal or Publication Title: Fungal Biology Reviews
    Publisher: Elsevier
    Refereed: Yes
    URI:

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