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    Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy


    Khan, Faheem and Mat, Arimin and Hogan, Andrew E. and Kent, Brian D. and Eigenheer, Sonia and Corrigan, Michelle and O'Shea, Donal and Butler, Marcus W. (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM: An International Journal of Medicine, 110 (12). pp. 853-854. ISSN 1460-2725

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    Abstract

    The QJM has recently published reviews of novel therapies in chronic airways disease.1 There is a potentially novel role for glucagon-like peptide 1 (GLP-1) agonists in obesity-related, metabolic asthma, though clinical trial data are lacking.2 On the basis of work with other inflammatory states, we hypothesised that clinically-indicated use of GLP-1 agonists for glycaemic control in type 2 diabetes mellitus (T2DM) would be safe in those with concomitant asthma, potentially leading to improved asthma control and fewer asthma exacerbations.3 In a pilot observational cohort study, we prospectively identified nine patients with pulmonologist-diagnosed asthma (never-smokers) and concomitant T2DM who were about to be initiated on clinically-indicated liraglutide for T2DM in the course of routine clinical care, and assessed them for asthma-related indices at baseline and 52 weeks after initiating liraglutide. All received routine asthma care. Baseline characteristics of the study cohort are as shown (Table 1)...

    Item Type: Article
    Keywords: Medicine, general & internat; Receptor; obesity; Asthma;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 11565
    Identification Number: https://doi.org/10.1093/qjmed/hcx125
    Depositing User: Andrew Hogan
    Date Deposited: 01 Nov 2019 16:45
    Journal or Publication Title: QJM: An International Journal of Medicine
    Publisher: Oxford University Press
    Refereed: Yes
    URI:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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