Butler, Marion P. and Wang, Steven I. and Chaganti, R.S.K. and Parsons, Ramon and Dalla-Favera, Riccardo (1999) Analysis of PTEN Mutations and Deletions in B-Cell Non-Hodgkin’s Lymphomas. Genes, Chromosomes and Cancer, 24. pp. 322-327. ISSN 1045-2257

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Abstract

The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. The PTEN gene product is a dual-specificity phosphatase with putative tumor suppressor function. Deletions and rearrangements of 10q22–25 have been reported in ,5%–10% of non-Hodgkin’s lymphomas (NHLs), raising the possibility of PTEN involvement in these tumors. In order to address this question, we analyzed a panel of NHLs (n 5 74) representative of the main histologic subtypes for mutations and homozygous deletions of PTEN. We report somatic coding/splice site mutations in 20% (2 of 10) of Burkitt’s lymphoma cell lines and in 3% (2 of 64) of primary NHL cases analyzed. No homozygous deletions were found in these tumors. Interestingly, this study showed that cytogenetically characterized NHL cases (n 5 6) with 10q22–q25 abnormalities displayed neither biallelic deletions nor mutations of PTEN. These results suggest that a tumor suppressor gene distinct from PTEN may be involved in 10q deletions in this subgroup of NHL cases.

Item Type:	Article
Keywords:	Analysis; PTEN Mutations; Deletions; B-Cell; Non-Hodgkin’s Lymphomas;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	12357
Depositing User:	Marion Butler
Date Deposited:	04 Feb 2020 16:38
Journal or Publication Title:	Genes, Chromosomes and Cancer
Publisher:	Wiley Online Library
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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