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    Analysis of PTEN Mutations and Deletions in B-Cell Non-Hodgkin’s Lymphomas


    Butler, Marion P. and Wang, Steven I. and Chaganti, R.S.K. and Parsons, Ramon and Dalla-Favera, Riccardo (1999) Analysis of PTEN Mutations and Deletions in B-Cell Non-Hodgkin’s Lymphomas. Genes, Chromosomes and Cancer, 24. pp. 322-327. ISSN 1045-2257

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    Abstract

    The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. The PTEN gene product is a dual-specificity phosphatase with putative tumor suppressor function. Deletions and rearrangements of 10q22–25 have been reported in ,5%–10% of non-Hodgkin’s lymphomas (NHLs), raising the possibility of PTEN involvement in these tumors. In order to address this question, we analyzed a panel of NHLs (n 5 74) representative of the main histologic subtypes for mutations and homozygous deletions of PTEN. We report somatic coding/splice site mutations in 20% (2 of 10) of Burkitt’s lymphoma cell lines and in 3% (2 of 64) of primary NHL cases analyzed. No homozygous deletions were found in these tumors. Interestingly, this study showed that cytogenetically characterized NHL cases (n 5 6) with 10q22–q25 abnormalities displayed neither biallelic deletions nor mutations of PTEN. These results suggest that a tumor suppressor gene distinct from PTEN may be involved in 10q deletions in this subgroup of NHL cases.

    Item Type: Article
    Keywords: Analysis; PTEN Mutations; Deletions; B-Cell; Non-Hodgkin’s Lymphomas;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12357
    Depositing User: Marion Butler
    Date Deposited: 04 Feb 2020 16:38
    Journal or Publication Title: Genes, Chromosomes and Cancer
    Publisher: Wiley Online Library
    Refereed: Yes
    URI:

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