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    The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism


    Hams, Emily and Bermingham, Rachel and Wurlod, Felicity A. and Hogan, Andrew and O'Shea, Donal and Preston, Roger J. and Rodewald, Hans-Reimer and McKenzie, Andrew N.J. and Fallon, Padraic G. (2016) The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism. The FASEB Journal, 30. pp. 824-835. ISSN 0892-6638

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    Abstract

    Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived v1 (v1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activated macrophages in the adipose tissue. IL-33 release from cells in the adipose tissue is mediated by the RNase activity of v1; however, the ability of v1 to improve metabolic status is reliant upon effective binding of v1 to CD206. We demonstrate a novel mechanism for RNasemediated release of IL-33 inducing ILC2-dependent improvements in the metabolic status of obese animals.— Hams, E., Bermingham, R., Wurlod, F. A., Hogan, A. E., O’Shea, D., Preston, R. J., Rodewald, H.-R., McKenzie, A. N. J., Fallon, P. G. The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism.

    Item Type: Article
    Keywords: obesity; adipocytes; inflammation;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12402
    Identification Number: https://doi.org/10.1096/fj.15-277822
    Depositing User: Andrew Hogan
    Date Deposited: 10 Feb 2020 17:44
    Journal or Publication Title: The FASEB Journal
    Publisher: Federation of American Society of Experimental Biology
    Refereed: Yes
    URI:

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