Carolan, Eirin and Tobin, Laura M. and Mangan, Bozgana A. and Corrigan, Michelle and Gaoatswe, Gadintshware and Byrne, Greg and Geoghegan, Justin and Cody, Declan and O'Connell, Jean and Winter, Desmond C and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal and Hogan, Andrew E. (2015) Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity. Journal of Immunology, 194 (12). pp. 5775-5780. ISSN 0022-1767

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Abstract

Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through the rapid production of cytokines. In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion is associated with diabetic status. Circulating MAIT cells more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated in insulin resistance. MAIT cells were enriched in adipose tissue (AT) compared with blood. AT MAIT cells, but not circulating MAIT cells, were capable of producing IL-10. In AT from obese subjects, MAIT cells were depleted, were less likely to produce IL-10, and more frequently produced IL-17. Finally, we show that IL-17+ MAIT cells are also increased in childhood obesity, and altered MAIT cell frequencies in obese children are positively associated with insulin resistance. These data indicate that MAIT cells are enriched in human AT and display an IL-17+ phenotype in both obese adults and children, correlating with levels of insulin resistance. The alterations in MAIT cells may be contributing to obesity-related sterile inflammation and insulin resistance.

Item Type:	Article
Keywords:	Altered Distribution; Increased IL-17; Mucosal-Associated Invariant; T Cells; Adult Obesity; Childhood Obesity; Obesity;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	12408
Identification Number:	https://doi.org/10.4049/jimmunol.1402945
Depositing User:	Andrew Hogan
Date Deposited:	13 Feb 2020 10:52
Journal or Publication Title:	Journal of Immunology
Publisher:	American Association of Immunologists
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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