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    Correlation between maternal inflammatory markers and fetomaternal adiposity


    Farah, Nadine and Hogan, Andrew and O'Connor, Norah and Kennelly, Mairead M. and O'Shea, Donal and Turner, Michael J. (2012) Correlation between maternal inflammatory markers and fetomaternal adiposity. Cytokine, 60 (1). pp. 96-99. ISSN 1043-4666

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    Abstract

    Outside pregnancy, both obesity and diabetes mellitus are associated with changes in inflammatory cytokines. Obesity in pregnancy may be complicated by gestational diabetes mellitus (GDM) and/or fetal macrosomia. The objective of this study was to determine the correlation between maternal cytokines and fetomaternal adiposity in the third trimester in women where the important confounding variable GDM had been excluded. Healthy women with a singleton pregnancy and a normal glucose tolerance test at 28 weeks gestation were enrolled at their convenience. Maternal cytokines were measured at 28 and 37 weeks gestation. Maternal adiposity was assessed indirectly by calculating the Body Mass Index (BMI), and directly by bioelectrical impedance analysis. Fetal adiposity was assessed by ultrasound measurement of fetal soft tissue markers and by birthweight at delivery. Of the 71 women studied, the mean maternal age and BMI were 29.1 years and 29.2 kg/m2 respectively. Of the women studied 32 (45%) were obese. Of the cytokines, only maternal IL-6 and IL-8 correlated with maternal adiposity. Maternal TNF-a, IL-b, IL-6 and IL-8 levels did not correlate with either fetal body adiposity or birthweight. In this well characterised cohort of pregnant non-diabetic women in the third trimester of pregnancy we found that circulating maternal cytokines are associated with maternal adiposity but not with fetal adiposity.

    Item Type: Article
    Keywords: Cytokines; Interleukin; Maternal body composition; Fetal body composition; Birthweight;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12432
    Identification Number: https://doi.org/10.1016/j.cyto.2012.05.024
    Depositing User: Andrew Hogan
    Date Deposited: 17 Feb 2020 15:55
    Journal or Publication Title: Cytokine
    Publisher: Elsevier
    Refereed: Yes
    URI:

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