Hogan, Andrew E. and Corrigan, Michelle and O'Reilly, Vincent P. and Gaoatswe, G. and O'Connell, Jean and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal
(2011)
Cigarette smoke alters the invariant natural killer
T cell function and may inhibit anti-tumor responses.
Clinical Immunology, 140.
pp. 229-235.
ISSN 1521-6616
Abstract
Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express
the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT
cells are important immune regulators and can initiate anti-tumor responses through early potent
cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke
contains many carcinogens and is implicated directly and indirectly in many cancers. We
investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We
found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant
NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine
production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or
CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor
responses, which may contribute to the role of smoking in the development of cancer.
| Item Type: |
Article
|
| Keywords: |
iNKT cells;
Cigarette smoke;
Anti-tumor responses; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
12435 |
| Identification Number: |
https://doi.org/10.1016/j.clim.2011.01.011 |
| Depositing User: |
Andrew Hogan
|
| Date Deposited: |
17 Feb 2020 16:41 |
| Journal or Publication Title: |
Clinical Immunology |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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