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    Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes


    Barrett, Stephen and Delaney, Stephen and Kavanagh, Kevin and Montagner, Diego (2018) Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes. Inorganica Chimica Acta, 479. pp. 261-265. ISSN 0020-1693

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    Abstract

    A pioneer series of copper(II) complexes bearing planar phenanthroline-modified aromatic ligands and steroid (ethynylestradiol and ethisterone) with generic formula [Cu(N \ N)(steroid)](NO3)2 where N \ N is DPQ, DPPZ and DPPN and steroid is estradiol or testosterone, were synthetized, characterised and screened in vitro and in vivo as antimicrobial agents against Staphylococcus aureus and methicillin resistant Staphylococcus aureus (MRSA). Toxicity studies revealed notable antibacterial activity of the copper – based compounds, which is significantly increased in vivo by the presence of the steroid moiety. Toxicity profiling was estimated in vitro versus Gram-positive (Staphylococcus aureus) and MRSA and in vivo in Galleria mellonella larvae infected with S. aureus. Results showed the complexes to be active against S. aureus and MRSA in vitro (MIC50 average value of 2.46 and 97 lM in S. aureus and MRSA, respectively) and to be active when larvae infected with S. aureus were administered the agents.

    Item Type: Article
    Keywords: Copper(II); Phenanthroline; Steroids; Antimicrobial; In vivo;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Chemistry
    Item ID: 12439
    Identification Number: https://doi.org/10.1016/j.ica.2018.04.054
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 17 Feb 2020 16:58
    Journal or Publication Title: Inorganica Chimica Acta
    Publisher: Elsevier
    Refereed: Yes
    URI:

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