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    Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment


    Kagalwalla, Amir F. and Akhtar, Noorain and Woodruff, Samantha A. and Rea, Bryan A. and Masterson, Joanne C. and Mukkada, Vince and Parashette, Kalyan R. and Du, Jian and Fillon, Sophie A. and Protheroe, Cheryl A. and Lee, James J. and Amsden, Katie and Melin-Aldana, Hector and Capocelli, Kelley E. and Furuta, Glenn T. and Ackerman, Steven J. (2012) Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. Journal of Allergy and Clinical Immunology, 129 (5). 1387-1396.e7. ISSN 1097-6825

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    Abstract

    Background: Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated. Objectives: We sought to explore a role for epithelial mesenchymal transition (EMT) in subjects with EoE and determine whether EMT resolves with treatment. Methods: Esophageal biopsy specimens from 60 children were immunostained for epithelial (cytokeratin) and mesenchymal (vimentin) EMT biomarkers, and EMT was quantified.

    Item Type: Article
    Keywords: Eosinophil; esophagitis; epithelium; remodeling; fibrosis; mesenchymal; vimentin; cytokeratin;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12493
    Identification Number: https://doi.org/10.1016/j.jaci.2012.03.005
    Depositing User: Joanne Masterson
    Date Deposited: 27 Feb 2020 15:11
    Journal or Publication Title: Journal of Allergy and Clinical Immunology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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