Fredj, Zina and Ben Ali, Mounir and Singh, Baljit and Dempsey, Eithne
(2018)
Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers.
Microchimica Acta, 185.
p. 412.
ISSN 1436-5073
Abstract
The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01–100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days.
| Item Type: |
Article
|
| Keywords: |
5-Hydroxyindole-3-acetic acid;
5-Hydroxytryptamine;
Pt nanocomposites;
Pyrrole-3-carboxylic acid;
Stripping square wave voltammetry;
Quantitation in artificial urine; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
12518 |
| Identification Number: |
https://doi.org/10.1007/s00604-018-2949-5 |
| Depositing User: |
Eithne Dempsey
|
| Date Deposited: |
05 Mar 2020 15:56 |
| Journal or Publication Title: |
Microchimica Acta |
| Publisher: |
Springer |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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