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    Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers


    Fredj, Zina and Ben Ali, Mounir and Singh, Baljit and Dempsey, Eithne (2018) Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers. Microchimica Acta, 185. p. 412. ISSN 1436-5073

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    Abstract

    The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01–100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days.

    Item Type: Article
    Keywords: 5-Hydroxyindole-3-acetic acid; 5-Hydroxytryptamine; Pt nanocomposites; Pyrrole-3-carboxylic acid; Stripping square wave voltammetry; Quantitation in artificial urine;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 12518
    Identification Number: https://doi.org/10.1007/s00604-018-2949-5
    Depositing User: Eithne Dempsey
    Date Deposited: 05 Mar 2020 15:56
    Journal or Publication Title: Microchimica Acta
    Publisher: Springer
    Refereed: Yes
    URI:

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