Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers

Fredj, Zina; Ben Ali, Mounir; Singh, Baljit; Dempsey, Eithne

Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers

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Fredj, Zina, Ben Ali, Mounir, Singh, Baljit and Dempsey, Eithne (2018) Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers. Microchimica Acta, 185. p. 412. ISSN 1436-5073

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Abstract

The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01–100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days.

Item Type:	Article
Keywords:	5-Hydroxyindole-3-acetic acid; 5-Hydroxytryptamine; Pt nanocomposites; Pyrrole-3-carboxylic acid; Stripping square wave voltammetry; Quantitation in artificial urine;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	12518
Identification Number:	10.1007/s00604-018-2949-5
Depositing User:	Eithne Dempsey
Date Deposited:	05 Mar 2020 15:56
Journal or Publication Title:	Microchimica Acta
Publisher:	Springer
Refereed:	Yes
Related URLs:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

MURAL - Maynooth University Research Archive Library

Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers

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