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Fredj, Zina, Ben Ali, Mounir, Singh, Baljit and Dempsey, Eithne (2018) Simultaneous voltammetric detection of 5-hydroxyindole acetic acid and 5-hydroxytryptamine at an electropolymerised glassy carbon transducer modified with platinised carbon nanofibers. Microchimica Acta, 185. p. 412. ISSN 1436-5073
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Abstract
The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01–100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days.
| Item Type: | Article |
|---|---|
| Keywords: | 5-Hydroxyindole-3-acetic acid; 5-Hydroxytryptamine; Pt nanocomposites; Pyrrole-3-carboxylic acid; Stripping square wave voltammetry; Quantitation in artificial urine; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 12518 |
| Identification Number: | 10.1007/s00604-018-2949-5 |
| Depositing User: | Eithne Dempsey |
| Date Deposited: | 05 Mar 2020 15:56 |
| Journal or Publication Title: | Microchimica Acta |
| Publisher: | Springer |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/12518 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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