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    Role of Eosinophils in Inflammatory Bowel and Gastrointestinal Diseases


    Woodruff, Samantha A. and Masterson, Joanne C. and Fillon, Sophie A. and Robinson, Zachary and Furuta, Glenn T. (2011) Role of Eosinophils in Inflammatory Bowel and Gastrointestinal Diseases. Journal of Pediatric Gastroenterology and Nutrition, 52 (6). pp. 650-661. ISSN 1536-4801

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    Abstract

    Inflammatory bowel diseases (IBD) are characterized by the invasion of leukocytes into the intestinal mucosa. However, a mixed inflammatory picture is observed that includes neutrophils, lymphocytes, monocytes, and eosinophils. To this day, the role of eosinophils in health and in disease remains unclear. Investigations into their function stem primarily from allergic diseases, asthma, and parasitic infections. This makes it even more difficult to discern a role for the fascinating eosinophil in IBDs because, unlike the lung or the skin, eosinophils reside in normal intestinal mucosa and increase in disease states; consequently, an intricate system must regulate their migration and numbers. These granulocytes are equipped with the machinery to participate in gastrointestinal (GI) inflammation and in the susceptible microenvironment, they may initiate or perpetuate an inflammatory response. A significant body of literature characterizes eosinophils present in the GI microenvironment where they have the potential to interact with other resident cells, thus promoting intestinal remodeling, mucus production, epithelial barrier, cytokine production, angiogenesis, and neuropeptide release. A number of lines of evidence support both potential beneficial and deleterious roles of eosinophils in the gut. Although studies from the gut and other mucosal organs suggest eosinophils affect mucosal GI inflammation, definitive roles for eosinophils in IBDs await discovery.

    Item Type: Article
    Keywords: Crohn disease; eosinophil; inflammatory bowel disease; ulcerative colitis;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12566
    Identification Number: https://doi.org/10.1097/MPG.0b013e3182128512
    Depositing User: Joanne Masterson
    Date Deposited: 10 Mar 2020 17:03
    Journal or Publication Title: Journal of Pediatric Gastroenterology and Nutrition
    Publisher: Lippincott, Williams & Wilkins
    Refereed: Yes
    URI:

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