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    Purinergic Signaling During Immune Cell Trafficking


    Ferrari, Davide and McNamee, Eóin N. and Idzko, Marco and Gambari, Roberto and Eltzschig, Holger K. (2016) Purinergic Signaling During Immune Cell Trafficking. Trends in Immunology, 37 (6). pp. 399-411. ISSN 1471-4906

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    Abstract

    Migration and positioning of immune cells is fundamental for their differentiation and recruitment at sites of infection. Besides the fundamental role played by chemokines and their receptors, recent studies demonstrate that a complex network of purinergic signaling events plays a key role in these trafficking events. This process includes the release of nucleotides (such as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors. At the same time, surface-expressed ectoapyrases and nucleotidases convert extracellular nucleotides to adenosine, and adenosine signaling events play additional functional roles in leucocyte trafficking. In this review we revisit classical paradigms of inflammatory cell trafficking in the context of recent studies implicating purinergic signaling events in this process.

    Item Type: Article
    Keywords: Purinergic; Signaling; Immune Cell; Trafficking;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12571
    Identification Number: https://doi.org/10.1016/j.it.2016.04.004
    Depositing User: Eoin McNamee
    Date Deposited: 20 Mar 2020 11:01
    Journal or Publication Title: Trends in Immunology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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