McNamee, Eóin N. and Korns Johnson, Darlynn and Homann, Dirk and Clambey, Eric T.
(2013)
Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function.
Immunologic Research, 55 (1-3).
pp. 58-70.
ISSN 1559-0755
Abstract
Oxygen is a molecule that is central to cellular respiration and viability, yet there are multiple physiologic and
pathological contexts in which cells experience conditions of insufficient oxygen availability, a state known as hypoxia.
Given the metabolic challenges of a low oxygen environment, hypoxia elicits a range of adaptive responses at the cellular,
tissue, and systemic level to promote continued survival and function. Within this context, T lymphocytes are a highly
migratory cell type of the adaptive immune system that frequently encounters a wide range of oxygen tensions in both
health and disease. It is now clear that oxygen availability regulates T cell differentiation and function, a response
orchestrated in large part by the hypoxia-inducible factor transcription factors. Here, we discuss the physiologic scope of
hypoxia and hypoxic signaling, the contribution of these pathways in regulating T cell biology, and current gaps in our
understanding. Finally, we discuss how emerging therapies that modulate the hypoxic response may offer new modalities
to alter T cell function and the outcome of acute and chronic pathologies.
| Item Type: |
Article
|
| Keywords: |
T cell; Oxygen; Hypoxia; Hypoxia-inducible factor; Metabolism; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
12586 |
| Identification Number: |
https://doi.org/10.1007/s12026-012-8349-8 |
| Depositing User: |
Eoin McNamee
|
| Date Deposited: |
23 Mar 2020 12:12 |
| Journal or Publication Title: |
Immunologic Research |
| Publisher: |
Springer |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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