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    New insights into the regulation of TLR signaling


    Miggin, Sinead and O'Neill, Luke A.J. (2006) New insights into the regulation of TLR signaling. Journal Of Leukocyte Biology, 80. pp. 220-226. ISSN 1938-3673

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    Abstract

    Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our under- standing of how TLR signaling is regulated at the biochemical level.

    Item Type: Article
    Keywords: inflammation; regulatory molecules;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12629
    Identification Number: https://doi.org/10.1189/jlb.1105672
    Depositing User: Sinead Miggin
    Date Deposited: 26 Mar 2020 15:58
    Journal or Publication Title: Journal Of Leukocyte Biology
    Publisher: Wiley Online Library
    Refereed: Yes
    URI:

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