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    Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease


    Robinson, Mark W. and McGuinness, Dagmara and Swann, Rachael and Barclay, Stephen and Mills, Peter R. and Patel, Arvind H. and McLauchlan, John and Shiels, Paul G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12. pp. 1141-1143. ISSN 1474-9718

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    Abstract

    Chronic hepatitis C virus infection (C‐HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C‐HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C‐HC. Our results suggest that C‐HC induces non‐cell‐autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C‐HC and increased susceptibility to age‐associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.

    Item Type: Article
    Keywords: biological aging; CDKN2 locus; chronic HCV infection; telomere length;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12661
    Identification Number: https://doi.org/10.1111/acel.12125
    Depositing User: Mark Robinson
    Date Deposited: 30 Mar 2020 10:39
    Journal or Publication Title: Aging Cell
    Publisher: Wiley
    Refereed: Yes
    URI:

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