MURAL - Maynooth University Research Archive Library



    Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort


    English, Jane A. and Lopez, Lorna and O'Gorman, Aoife and Focking, Melanie and Hryniewicka, Magdalena and Scaife, Caitriona and Sabherwal, Sophie and Wynne, Kieran and Dicker, Patrick and Rutten, Bart P.F. and Lewis, Glynn and Zammit, Stanley and Cannon, Mary and Cagney, Gerard and Cotter, David R. (2018) Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort. Schizophrenia Bulletin, 44 (2). pp. 297-306. ISSN 0586-7614

    [img]
    Preview
    Download (9MB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying pathophysiological mechanisms. We undertook the first proteomic profiling of blood plasma samples of children who later develop a PD. Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who also participated in psychiatric assessment interviews at age 18. Protein expression levels at age 11 were compared between individuals who developed PD at age 18 (n = 37) with population-based agematched controls (n = 38). Sixty out of 181 plasma proteins profiled were found to be differentially expressed (P < .05) in children with an outcome of the PD. Thirty-four of these proteins were found to be differentially expressed following correction for multiple comparisons. Pathway analysis implicated the complement and coagulation cascade. A second, targeted proteomic approach was used to verify these findings in age 11 plasma from subjects who reported psychotic experiences at age 18 (n = 40) in comparison to age-matched controls (n = 66). Our findings indicate that the complement and coagulation system is dysregulated in the blood during childhood before the development of the PD.

    Item Type: Article
    Keywords: ALSPAC; complement; coagulation; plasma; proteomics; psychotic disorder; schizophrenia;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 13187
    Identification Number: https://doi.org/10.1093/schbul/sbx075
    Depositing User: Lorna Lopez
    Date Deposited: 14 Aug 2020 15:22
    Journal or Publication Title: Schizophrenia Bulletin
    Publisher: Oxford University Press
    Refereed: Yes
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year