Schroeder, Martina and Bowie, Andrew G.
(2005)
TLR3 in antiviral immunity: key player or bystander?
Trends in Immunology, 26 (9).
pp. 462-468.
ISSN 1471-4906
Abstract
Toll-like receptor 3 (TLR3), which recognizes double-stranded (ds)RNA, was the first identified antiviral TLR and, because dsRNA is a universal viral molecular pattern, TLR3 has been assumed to have a central role in the host response to viruses. However, this role has recently been questioned by in vivo studies and the discovery of several other antiviral pattern-recognition receptors. In this review, the function of TLR3 in the context of these other receptors, namely TLR7, 8 and 9 and the newly identified dsRNA-receptor retinoic-acid inducible gene-I (RIG-I) is discussed. Also, recent research concerning the expression profile of TLR3, its evasion by viruses and a potential role in crosspriming is addressed, which reveals a clearer appreciation of the contribution of TLR3 to antiviral immunity.
| Item Type: |
Article
|
| Additional Information: |
Cite as: Martina Schröder, Andrew G. Bowie,
TLR3 in antiviral immunity: key player or bystander?,
Trends in Immunology,
Volume 26, Issue 9,
2005,
Pages 462-468,
ISSN 1471-4906,
https://doi.org/10.1016/j.it.2005.07.002. Funding: Work in our laboratory is supported by Science Foundation Ireland, The
Health Research Board and the Irish Research Council for Science,
Education and Technology (IRCSET). |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
13679 |
| Identification Number: |
https://doi.org/10.1016/j.it.2005.07.002 |
| Depositing User: |
Martina Schroeder
|
| Date Deposited: |
27 Nov 2020 16:04 |
| Journal or Publication Title: |
Trends in Immunology |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| Funders: |
Science Foundation Ireland (SFI), Irish Research Council for Science, Education and Technology (IRCSET) |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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