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    Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases


    Kim, David Y. and Furuta, Glenn T. and Nguyen, Nathalie and Inage, Eisuke and Masterson, Joanne C. (2019) Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases. Journal of Pediatric Gastroenterology and Nutrition, 68 (5). pp. 611-614. ISSN 1536-4801

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    Abstract

    Our bodies are protected from the external environment by mucosal barriers that are lined by epithelial cells. The epithelium plays a critical role as a highly dynamic, selective semipermeable barrier that separates luminal contents and pathogens from the rest of the body as well as controlling the absorption of nutrients, fluid and solutes (1, 2). A series of protein complexes including the adherens junction, desmosomes, and tight junctions (TJ) function as the principal barrier in paracellular diffusion (3) as well as regulators of intracellular solute, protein and lipid transport (4). TJs are composed of a series of proteins called occludins, junctional adhesion molecules (JAM), and claudins (5, 6) that reside primarily as the most apical intercellular junction. Here we will review one of these protein families, claudins, and their relevance to gastrointestinal and liver diseases.

    Item Type: Article
    Additional Information: Published in final edited form as: J Pediatr Gastroenterol Nutr. 2019 May ; 68(5): 611–614. doi:10.1097/MPG.0000000000002301.
    Keywords: celiac disease; eosinophilic oesophagitis; inflammatory bowel disease; liver disease; tight junction;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 13995
    Identification Number: https://doi.org/10.1097/MPG.0000000000002301
    Depositing User: Joanne Masterson
    Date Deposited: 12 Feb 2021 10:34
    Journal or Publication Title: Journal of Pediatric Gastroenterology and Nutrition
    Publisher: Lippincott, Williams & Wilkins
    Refereed: Yes
    URI:

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