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    Establishment of Functional B Cell Memory Against Parvovirus B19 Capsid Proteins May be Associated With Resolution of Persistent Infection


    Corcoran, A. and Crowley, B. and Dewhurst, C. and Pizer, B.L. and Doyle, Sean (2006) Establishment of Functional B Cell Memory Against Parvovirus B19 Capsid Proteins May be Associated With Resolution of Persistent Infection. Journal of Medical Virology, 78 (1). pp. 125-128. ISSN 0146-6615

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    Abstract

    Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non-structural protein 1 (NS1). Determination of antigen-specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection.

    Item Type: Article
    Keywords: ALL; immunocompromised; B cell ELISpot; leukemia; erythrovirus;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 296
    Identification Number: https://doi.org/10.1002/jmv.20513
    Depositing User: Dr. Sean Doyle
    Date Deposited: 08 Sep 2006
    Journal or Publication Title: Journal of Medical Virology
    Publisher: Wiley Liss, Inc.
    Refereed: Yes
    URI:

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