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    In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes


    McCann, Malachy and Santos, Andre L. S. and Da Silva, Bianca A. and Romanos, Maria Teresa V. and Pyrrho, Alexandre S. and Devereux, Michael and Kavanagh, Kevin and Fichtnerg, Iduna and Kellett, Andrew (2012) In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes. Toxicology Research, 1 (1). pp. 47-54. ISSN 2045-452X

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    Abstract

    1,10-Phenanthroline (phen, 5), 1,10-phenanthroline-5,6-dione (phendione, 6), [Cu(phendione)3]- (ClO4)2·4H2O (12) and [Ag(phendione)2]ClO4 (13) are highly active, in vitro, against a range of normal and cancerous mammalian cells, fungal and insect cell lines, with the metal complexes offering a clear enhancement in activity. Cytoselectivity was not observed between the tumorigenic and non-tumorigenic mammalian lines. In in vivo tests, using Galleria mellonella and Swiss mice, all four compounds were well tolerated in comparison to the clinical agent, cisplatin. In addition, blood samples taken from the Swiss mice showed that the levels of the hepatic enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), remained unaffected. Immunocompromised nude mice showed a much lower tolerance to 13 and, subsequently, when these mice were implanted with Hep-G2 (hepatic) and HCT-8 (colon) human-derived tumors, there was no influence on tumor growth.

    Item Type: Article
    Additional Information: The definitive version of this article is available at DOI: 10.1039/c2tx00010e
    Keywords: In vitro; in vivo; biological activities; 1,10-phenanthroline; 1,10-phenanthroline-5,6-dione; copper(II; silver(I); complexes; Cytoselectivity; turmour; cancer;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 4231
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 28 Feb 2013 09:48
    Journal or Publication Title: Toxicology Research
    Publisher: RSC Publishing
    Refereed: Yes
    URI:

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