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    Selective Michael additions to alkylidenemalonates using thiourea-based bifunctional organocatalysts


    Gavin, Declan P. and Stephens, John C. (2013) Selective Michael additions to alkylidenemalonates using thiourea-based bifunctional organocatalysts. Arkivoc, 4. pp. 76-87. ISSN 1551-7012

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    Abstract

    Bifunctional thiourea catalysts have been found to be excellent promoters of the challenging Michael addition to alkylidenemalonates giving high yields of up to 99%. Substrate structure was important for enantiodiscrimination, with aryl alkylidenemalonate acceptors furnishing products with ee values of up to 73%.

    Item Type: Article
    Additional Information: Published under a Creative Commons Attribution Non-Commercial License
    Keywords: Organocatalysis; alkylidenemalonates; β-diketones; nitromethane; Michael addition; bifunctional thiourea catalysts;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 6335
    Depositing User: Dr John Stephens
    Date Deposited: 07 Sep 2015 09:13
    Journal or Publication Title: Arkivoc
    Publisher: Arkat USA Inc.
    Refereed: Yes
    URI:

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