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    Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response


    Maffioletti, Sara Martina and Noviello, Maddalena and English, Karen and Tedesco, Francesco Saverio (2014) Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response. Boomed Research International (964010). ISSN 2314-6141

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    Abstract

    Treating muscle disorders poses several challenges to the rapidly evolving field of regenerative medicine. Considerable progress has been made in isolating, characterizing, and expanding myogenic stem cells and, although we are now envisaging strategies to generate very large numbers of transplantable cells (e.g., by differentiating induced pluripotent stemcells), limitations directly linked to the interaction between transplanted cells and the host will continue to hamper a successful outcome. Among these limitations, host inflammatory and immune responses challenge the critical phases after cell delivery, including engraftment, migration, and differentiation. Therefore, it is key to study the mechanisms and dynamics that impair the efficacy of cell transplants in order to develop strategies that can ultimately improve the outcome of allogeneic and autologous stemcell therapies, in particular for severe disease such as muscular dystrophies. In this review we provide an overview of the main players and issues involved in this process and discuss potential approaches that might be beneficial for future regenerative therapies of skeletal muscle.

    Item Type: Article
    Keywords: Stem Cell Transplantation; Muscular Dystrophy; Challenge; Immune Response;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6836
    Identification Number: https://doi.org/10.1155/2014/964010
    Depositing User: Karen English
    Date Deposited: 19 Jan 2016 15:02
    Journal or Publication Title: Boomed Research International
    Publisher: Hindawi Publishing Corporation
    Refereed: Yes
    URI:

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