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    Mesenchymal Stromal Cells: Facilitators of Successful Transplantation?


    English, Karen and French, Anna and Wood, Kathryn J. (2010) Mesenchymal Stromal Cells: Facilitators of Successful Transplantation? Cell Stem Cell, 7. pp. 431-442. ISSN 1875-9777

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    Abstract

    Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory and reparative properties. Through specific interactions with immune cells that participate in both innate and adaptive responses, MSCs exposed to an inflammatory microenvironment can downregulate many immune effector functions. Clinical trials focusing onMSCsto treat graft-versus-host disease (GvHD) and autoimmune diseases are underway. Current analyses suggest that MSCs will improve cell and solid organ transplantation by ameliorating rejection and possibly eliminating the requirement for prolonged regimens of conventional immunosuppressive drugs. This review examines the in vitro and in vivo evidence for the clinical use of bone marrow derived MSCs.

    Item Type: Article
    Keywords: Mesenchymal Stromal Cells; Facilitators; Successful Transplantation;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6837
    Identification Number: https://doi.org/10.1016/j.stem.2010.09.009
    Depositing User: Karen English
    Date Deposited: 19 Jan 2016 15:52
    Journal or Publication Title: Cell Stem Cell
    Publisher: Elsevier
    Refereed: Yes
    URI:

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