Griffin, Matthew D. and Elliman, Stephen J and Cahill, Emer and English, Karen
(2013)
Concise Review: Adult Mesenchymal Stromal Cell Therapy for
Inflammatory Diseases: How Well Are We Joining the Dots?
Stem Cells, 31.
pp. 2033-2041.
ISSN 1549-4918
Abstract
Mesenchymal stromal (stem) cells (MSCs) continue to be a
strong area of focus for academic- and industry-based
researchers who share the goal of expanding their therapeutic
use for diverse inflammatory and immune-mediated
diseases. Recently, there has been an accelerated rate of
scientific publication, clinical trial activity, and commercialisation
in the field. This has included the reporting of
exciting new developments in four areas that will be of
key importance to future successful use of MSC-based
therapies in large numbers of patients: (a) fundamental
biology of the primary cells in bone marrow and other tissues
that give rise to MSCs in culture. (b) Mechanisms by
which MSCs modulate immune and inflammatory
responses in vivo. (c) Insights into MSC kinetics, safety,
and efficacy in relevant animal disease models. (d)
Isolation, definition, and clinical trial-based testing of
human MSCs by biomedical companies and academic
medical centers. Despite this progress, it remains unclear
whether MSCs will enter mainstream therapeutic practice
as a frequently used alternative to pharmacotherapy or
surgical/radiological procedures in the foreseeable future.
In this review, we summarize some of the most significant
new developments for each of the four areas that contribute
to the process of translating MSC research to the clinical
arena. In the context of this recent progress, we
discuss key challenges and specific knowledge gaps which,
if not addressed in a coordinated fashion, may hinder the
creation of robust “translational pipelines” for consolidating
the status of MSC-based therapies.
| Item Type: |
Article
|
| Keywords: |
Mesenchymal stem cells; Inflammation; Clinical trials; Cell therapy; Autoimmunity; Immunosuppression; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6840 |
| Identification Number: |
https://doi.org/10.1002/stem.1452 |
| Depositing User: |
Karen English
|
| Date Deposited: |
19 Jan 2016 16:28 |
| Journal or Publication Title: |
Stem Cells |
| Publisher: |
Wiley |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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