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    Concise Review: Adult Mesenchymal Stromal Cell Therapy for Inflammatory Diseases: How Well Are We Joining the Dots?


    Griffin, Matthew D. and Elliman, Stephen J and Cahill, Emer and English, Karen (2013) Concise Review: Adult Mesenchymal Stromal Cell Therapy for Inflammatory Diseases: How Well Are We Joining the Dots? Stem Cells, 31. pp. 2033-2041. ISSN 1549-4918

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    Abstract

    Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for academic- and industry-based researchers who share the goal of expanding their therapeutic use for diverse inflammatory and immune-mediated diseases. Recently, there has been an accelerated rate of scientific publication, clinical trial activity, and commercialisation in the field. This has included the reporting of exciting new developments in four areas that will be of key importance to future successful use of MSC-based therapies in large numbers of patients: (a) fundamental biology of the primary cells in bone marrow and other tissues that give rise to MSCs in culture. (b) Mechanisms by which MSCs modulate immune and inflammatory responses in vivo. (c) Insights into MSC kinetics, safety, and efficacy in relevant animal disease models. (d) Isolation, definition, and clinical trial-based testing of human MSCs by biomedical companies and academic medical centers. Despite this progress, it remains unclear whether MSCs will enter mainstream therapeutic practice as a frequently used alternative to pharmacotherapy or surgical/radiological procedures in the foreseeable future. In this review, we summarize some of the most significant new developments for each of the four areas that contribute to the process of translating MSC research to the clinical arena. In the context of this recent progress, we discuss key challenges and specific knowledge gaps which, if not addressed in a coordinated fashion, may hinder the creation of robust “translational pipelines” for consolidating the status of MSC-based therapies.

    Item Type: Article
    Keywords: Mesenchymal stem cells; Inflammation; Clinical trials; Cell therapy; Autoimmunity; Immunosuppression;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6840
    Identification Number: https://doi.org/10.1002/stem.1452
    Depositing User: Karen English
    Date Deposited: 19 Jan 2016 16:28
    Journal or Publication Title: Stem Cells
    Publisher: Wiley
    Refereed: Yes
    URI:

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