English, Karen
(2013)
Mechanisms of mesenchymal stromal cell
immunomodulation.
Immunology and Cell Biology, 91.
pp. 19-26.
ISSN 1440-1711
Abstract
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell
therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and
modulate immune responses have been significantly advanced and we now have a clearer picture of the effects that MSCs have
on the immune system particularly in the context of inflammatory-mediated disorders. A number of mechanisms of action have
been reported in MSC immunomodulation, which encompass the secretion of soluble factors, induction of anergy, apoptosis,
regulatory T cells and tolerogenic dendritic cells. It is clear that MSCs modulate both innate and adaptive responses
and evidence is now emerging that the local microenvironment is key in the activation or licensing of MSCs to become
immunosuppressive. More recently, studies have suggested that MSCs have the capacity to sense their environment and have a
role in pathogen clearance in conjunction with the resolution of insult or injury. This review focuses on the mechanisms of MSC
immunomodulation discussing the multistep process of MSC localisation at sites of inflammation, the cross talk between MSCs
and the local microenvironment as well as the subsequent mechanisms of action used to resolve inflammation.
| Item Type: |
Article
|
| Keywords: |
mesenchymal stromal cells; immune modulation; cell contact; soluble factors; tolerogenic DC; Treg; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6841 |
| Identification Number: |
https://doi.org/10.1038/icb.2012.56 |
| Depositing User: |
Karen English
|
| Date Deposited: |
19 Jan 2016 16:31 |
| Journal or Publication Title: |
Immunology and Cell Biology |
| Publisher: |
Nature Publishing Group |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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