English, Karen and Tonlorenzi, Rossana and Cossu, Giulio and Wood, Kathryn J
(2013)
Mesoangioblasts Suppress T Cell Proliferation
Through IDO and PGE-2-Dependent Pathways.
Stem Cells and Development, 22 (3).
pp. 512-523.
ISSN 1547-3287
Abstract
Human mesoangioblasts are vessel-associated stem cells that are currently in phase I/II clinical trials for the
treatment of patients with Duchenne muscular dystrophy. To date, little is known about the effect of mesoangioblasts
on human immune cells and vice versa. We hypothesized that mesoangioblasts could modulate the
function of immune cells in a similar manner to mesenchymal stromal cells. Human mesoangioblasts did not
evoke, but rather potently suppressed human T-cell proliferation and effector function in vitro in a dose- and timedependent
manner. Furthermore, mesoangioblasts exert these inhibitory effects uniformly on human CD4+ and
CD8+ T cells in a reversible manner without inducing a state of anergy. Interferon (IFN)-g and tumor necrosis
factor (TNF)-a play crucial roles in the initial activation of mesoangioblasts. Indoleamine 2,3-dioxygenase (IDO)
and prostaglandin E-2 (PGE) were identified as key mechanisms of action involved in the mesoangioblast
suppression of T-cell proliferation. Together, these data demonstrate a previously unrecognized capacity of mesoangioblasts
to modulate immune responses.
| Item Type: |
Article
|
| Keywords: |
Mesoangioblasts Suppress T Cell Proliferation;
IDO; PGE-2-Dependent Pathways; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6844 |
| Identification Number: |
https://doi.org/10.1089/scd.2012.0386 |
| Depositing User: |
Karen English
|
| Date Deposited: |
19 Jan 2016 16:45 |
| Journal or Publication Title: |
Stem Cells and Development |
| Publisher: |
Mary Ann Liebert |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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