MURAL - Maynooth University Research Archive Library



    Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities


    McGinley, John and McCann, Malachy and Ni, Kaijie and Tallon, Theresa M. and Kavanagh, Kevin and Devereux, Michael and Ma, Xiaomei and McKee, Vickie (2013) Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities. Polyhedron, 55. pp. 169-178. ISSN 0277-5387

    [img]
    Preview
    Download (309kB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldeh yde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo , towards Galleria mellonella . Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro , against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/j.poly.2013.03.023
    Keywords: Imidazoles; Schiff bases; Metal complexes; X-ray; Antimicrobial; Galleria mellonella;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6891
    Identification Number: https://doi.org/10.1016/j.poly.2013.03.023
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 20 Jan 2016 13:21
    Journal or Publication Title: Polyhedron
    Publisher: Elsevier
    Refereed: Yes
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year