McGinley, John and McCann, Malachy and Ni, Kaijie and Tallon, Theresa M. and Kavanagh, Kevin and Devereux, Michael and Ma, Xiaomei and McKee, Vickie (2013) Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities. Polyhedron, 55. pp. 169-178. ISSN 0277-5387

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Abstract

1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldeh yde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo , towards Galleria mellonella . Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro , against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.

Item Type:	Article
Additional Information:	The definitive published version of this article is available at DOI: 10.1016/j.poly.2013.03.023
Keywords:	Imidazoles; Schiff bases; Metal complexes; X-ray; Antimicrobial; Galleria mellonella;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	6891
Identification Number:	https://doi.org/10.1016/j.poly.2013.03.023
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	20 Jan 2016 13:21
Journal or Publication Title:	Polyhedron
Publisher:	Elsevier
Refereed:	Yes
URI:	http://www.sciencedirect.com/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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