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    Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives


    Dolan, Niamh and McGinley, John and Stephens, John C. and Kavanagh, Kevin and Hurley, Daniel and Maher, Niall (2014) Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives. Inorganica Chimica Acta, 409 (Part B). pp. 276-284. ISSN 0020-1693

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    Abstract

    The synthesis of several diorganotin(IV) dicarboxylate compounds, including acetates and nicotinates as well as diorganotin(IV) dichloride complexes of the ligands phen, dione and dppz were undertaken. Several difficulties in either the syntheses or complexation reactions with the organic ligands were encountered. The diorganotin(IV) dichloride complexes of the ligands (R2SnCl2L where R = Me, n-Bu or Ph and L = phen, dione or dppz) were tested against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The dibutyltin(IV) derivatives exhibited the broadest range of activity in comparison to the dimethyltin(IV) or diphenyltin(IV) derivatives. The addition of the nicotinate group did not promote activity against any of the bacteria. Furthermore, only in the case of Ph2SnCl2 dione was there improved activity compared to the organic ligand itself.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/j.ica.2013.09.038
    Keywords: Organotin halides and acetates; 1,10-Phenanthroline derivatives; NMR studies; Biological testing;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6893
    Identification Number: https://doi.org/10.1016/j.ica.2013.09.038
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 20 Jan 2016 13:20
    Journal or Publication Title: Inorganica Chimica Acta
    Publisher: Elsevier
    Refereed: Yes
    URI:

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