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    Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins


    McCormack, Natasha and O'Dea, Shirley (2013) Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins. Cellular Signalling, 25 (12). pp. 2856-2862. ISSN 0898-6568

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    Abstract

    Epithelial to mesenchymal transition (EMT) is a process inwhich fully differentiated epithelial cells losemany of their epithelial characteristics and adopt features typical of mesenchymal cells, thus allowing cells to become migratory and invasive. EMT is a critical process in development and its role in cancer and fibrosis is becoming increasingly recognised. It is also becoming apparent that EMT is not just restricted to embryonic development and disease in adults, but in fact may be an important process for the maintenance and regeneration of adult tissue architecture. While transforming growth factor-β (TGF-β) is considered a prototypic inducer of EMT, relatively little is known about other signalling molecules that regulate EMT. Bone morphogenic proteins (BMPs) are members of the TGF-β superfamily and 20 different human BMPs have been identified. Originally named for their effects on bone, these proteins are nowconsidered to be keymorphogenetic signals that orchestrate tissue architecture throughout the body. BMP2, -4 and -7 are the best studied to date. There are disparate reports of the roles of BMPs in EMT during development, cancer and fibrosis. Here, we present an overview of this literature as well as the emerging role of EMT in tissue regeneration and the involvement of BMPs in regulating this process.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/j.cellsig.2013.09.012
    Keywords: Bone morphogenetic proteins; Epithelial to mesenchymal transition; Regeneration; Morphogens; E-cadherin;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Institute of Immunology
    Item ID: 6932
    Identification Number: https://doi.org/10.1016/j.cellsig.2013.09.012
    Depositing User: Dr. Shirley O'Dea
    Date Deposited: 29 Jan 2016 15:38
    Journal or Publication Title: Cellular Signalling
    Publisher: Elsevier
    Refereed: Yes
    URI:

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