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    Comparison of plasmid-mediated quinolone resistance and extended-spectrum b-lactamases in third-generation cephalosporin-resistant Enterobacteriaceae from four Irish hospitals


    Walsh, Fiona and Rogers, Thomas R. (2012) Comparison of plasmid-mediated quinolone resistance and extended-spectrum b-lactamases in third-generation cephalosporin-resistant Enterobacteriaceae from four Irish hospitals. Journal of Medical Microbiology, 61. pp. 142-147. ISSN 0022-2615

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    Abstract

    In this study, the frequency of extended-spectrum b-lactamases (ESBL) and plasmid-mediated quinolone resistance (PMQR) mechanisms were investigated in 206 clinical isolates of third generation cephalosporin (3GC)-resistant Enterobacteriaceae in four hospitals in the Republic of Ireland. blaCTX-M-15 was the predominant ESBL gene. Of these 3GC resistant isolates, 54% were also resistant to ciprofloxacin. Investigation of the PMQR mechanisms revealed that the aac(69) Ib-cr gene predominated in fluoroquinolone-resistant (FQR) strains of Escherichia coli and Klebsiella pneumoniae, while the qnrA gene predominated in the FQR strains of Enterobacter. The blaCTX-M-15 gene was frequently identified with the aac(69)Ib-cr gene but was not always on the same plasmid. The prevalence of the blaCTX-M-15 gene appeared to be hospital-dependent. The epidemiology of both ESBL-producing and PMQR strains within the four hospitals indicated that their prevalence is not due to the spread of these resistance genes between isolates from different hospitals.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1099/jmm.0.035246-0
    Keywords: plasmid-mediated quinolone resistance; extended-spectrum b-lactamases; third-generation; cephalosporin-resistant Enterobacteriaceae;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6949
    Identification Number: https://doi.org/10.1099/jmm.0.035246-0
    Depositing User: Fiona Walsh
    Date Deposited: 04 Feb 2016 11:02
    Journal or Publication Title: Journal of Medical Microbiology
    Publisher: Society for General Microbiology
    Refereed: Yes
    Funders: Health Research Board (HRB)
    URI:

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