MURAL - Maynooth University Research Archive Library



    The EGFR demonstrates linear signal transmission


    Oyarzún, Diego A. and Bramhall, Jo L. and Lopez-Caamal, Fernando and Richards, Frances M. and Jodrell, Duncan I. and Krippendorff, Ben-Fillippo (2014) The EGFR demonstrates linear signal transmission. Integrative Biology, 6 (8). pp. 736-742. ISSN 1757-9694

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    Abstract

    Cells sense information encoded in extracellular ligand concentrations and process it using intracellular signalling cascades. Using mathematical modelling and high-throughput imaging of individual cells, we studied how a transient extracellular growth factor signal is sensed by the epidermal growth factor receptor system, processed by downstream signalling, and transmitted to the nucleus. We found that transient epidermal growth factor signals are linearly translated into an activated epidermal growth factor receptor integrated over time. This allows us to generate a simplified model of receptor signaling where the receptor acts as a perfect sensor of extracellular information, while the nonlinear input–output relationship of EGF-EGFR triggered signalling is a consequence of the downstream MAPK cascade alone.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1039/c4ib00062e
    Keywords: EGFR; linear signal transmission; epidermal growth factor receptor system;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 6962
    Identification Number: https://doi.org/10.1039/c4ib00062e
    Depositing User: Hamilton Editor
    Date Deposited: 05 Feb 2016 17:02
    Journal or Publication Title: Integrative Biology
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    Funders: National Biophotonics and Imaging Platform, Ireland, Cancer Research UK
    URI:

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