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    Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation


    English, Karen and Mahon, Bernard P. and Wood, Kathryn J. (2014) Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation. Current Drug Delivery, 11 (5). pp. 561-571. ISSN 1567-2018

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    Abstract

    Mesenchymal stromal cells (MSCs) participate in repair of damaged tissues, possess the potential to serve as a useful tool in the drug discovery field and exert immunosuppressive effects as demonstrated by their ability to modulate the immune response. Herein, the roles played by MSC differentiation and/or production of trophic factors involved in tissue repair are discussed. MSCs offer the opportunity to probe targets that conventional or differentiated cell lines do not express; thus providing a more refined system that allows identification of novel therapeutics. However, there are difficulties associated with drug discovery assays to which MSCs are not exempt. The immunosuppressive potential of MSCs has already been utilised in clinical trials where MSCs have been used to treat patients with graft- versus- host disease (GvHD) and autoimmune diseases. Another possible therapeutic application of MSCs lies in the field of transplantation tolerance. Although the capacity of MSCs to modulate immune responses has received much attention, the role of MSCs in transplantation tolerance is as yet unclear. In this review, we discuss the evidence for MSC induction of a state of tolerance in the transplantation setting.

    Item Type: Article
    Additional Information: This is the preprint version of the published article, which is available at DOI: 10.2174/1567201810999131125222440 . K.J.W. is supported by the EU consortium grant Optistem. K.E. is supported by the European commission under a Marie Curie Career Integration Grant and a HRB Translational Medicine Postdoctoral Fellowship. B.P.M. is supported by a Science Foundation Ireland Centre for Science and Engineering Technology (CSET) grant to the Regenerative Medicine Institute (REMEDI). The authors declare no potential conflict of interests.
    Keywords: Drug discovery; Mesenchymal stem cells; Mesenchymal stromal cells; Tissue repair; Transplantation tolerance;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7155
    Identification Number: https://doi.org/10.2174/1567201810999131125222440
    Depositing User: Bernard Mahon
    Date Deposited: 05 Jul 2016 13:46
    Journal or Publication Title: Current Drug Delivery
    Publisher: Bentham Science
    Refereed: Yes
    Funders: European Commission, Science Foundation Ireland (SFI)
    URI:

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