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    Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development


    Sarikaya-Bayram, Ozlem and Bayram, Ozgur and Feussner, Kirstin and Kim, Jong-Hwa and Kim, Hee-Soo and Kaever, Alexander and Feussner, Ivo and Chae, Keon-Sang and Han, Dong-Min and Han, Kap-Hoon and Braus, Gerhard H. (2014) Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development. Developmental Cell, 29 (4). pp. 406-420. ISSN 1534-5807

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    Official URL: http://dx.doi.org/10.1016/j.devcel.2014.03.020


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    Abstract

    Epigenetic and transcriptional control of gene expression must be coordinated in response to external signals to promote alternative multicellular developmental programs. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The VipC-VapB methyltransferases are tethered to the membrane by the FYVE-like zinc finger protein VapA, allowing the nuclear VelB-VeA-LaeA complex to activate transcription for sexual development. Once the release from VapA is triggered, VipCVapB is transported into the nucleus. VipC-VapB physically interacts with VeA and reduces its nuclear import and protein stability, thereby reducing the nuclear VelB-VeA-LaeA complex. Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3). This favors activation of the regulatory genes brlA and abaA, which promote the asexual program. The VapA-VipCVapB methyltransferase pathway combines control of nuclear import and stability of transcription factors with histone modification to foster appropriate differentiation responses.

    Item Type: Article
    Additional Information: The definitive version of this article is available at DOI: 10.1016/j.devcel.2014.03.020
    Keywords: Membrane-Bound; Methyltransferase Complex; VapA-VipC-VapB; Epigenetic Control; Fungal Development;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7182
    Depositing User: Ozgur Bayram
    Date Deposited: 13 Jul 2016 12:01
    Journal or Publication Title: Developmental Cell
    Publisher: Elsevier
    Refereed: Yes
    URI:

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