Moynagh, Paul N. (2005) The NF-κB pathway. Journal of Cell Science, 118. pp. 4589-4592. ISSN 0021-9533

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Abstract

The nuclear factor (NF)-κB transcription factor regulates expression of numerous components of the immune system (Li and Verma, 2002). These include proinflammatory cytokines, chemokines, adhesion molecules and inducible enzymes such as cycloxygenase-2 and inducible nitric oxide synthase, which regulate the innate immune response, as well as proteins that regulate the specific immune response, such as major histocompatibility complex and co-stimulatory molecules crucial to the induction phase of specific immunity, and cytokines like interleukin (IL)-2, IL-12 and interferon-γ that control lymphocyte proliferation and differentiation. Dysregulation of this transcription factor can thus lead to inflammatory and autoimmune diseases (Yamamoto and Gaynor, 2001). Since NF-κB also regulates the expression of a variety of proteins that inhibit apoptosis and promote cell survival/proliferation, it is also implicated in carcinogenesis (Karin et al., 2002).

Item Type:	Article
Keywords:	NF-κB; pathway; transcription factor; nuclear factor; proinflammatory cytokines; chemokines; adhesion molecules; cycloxygenase-2; inducible nitric oxide synthase; inducable enzymes;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	7198
Identification Number:	https://doi.org/10.1242/jcs.02579
Depositing User:	Professor Paul Moynagh
Date Deposited:	18 Jul 2016 15:58
Journal or Publication Title:	Journal of Cell Science
Publisher:	Company of Biologists
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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