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    The NF-κB pathway


    Moynagh, Paul N. (2005) The NF-κB pathway. Journal of Cell Science, 118. pp. 4589-4592. ISSN 0021-9533

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    Abstract

    The nuclear factor (NF)-κB transcription factor regulates expression of numerous components of the immune system (Li and Verma, 2002). These include proinflammatory cytokines, chemokines, adhesion molecules and inducible enzymes such as cycloxygenase-2 and inducible nitric oxide synthase, which regulate the innate immune response, as well as proteins that regulate the specific immune response, such as major histocompatibility complex and co-stimulatory molecules crucial to the induction phase of specific immunity, and cytokines like interleukin (IL)-2, IL-12 and interferon-γ that control lymphocyte proliferation and differentiation. Dysregulation of this transcription factor can thus lead to inflammatory and autoimmune diseases (Yamamoto and Gaynor, 2001). Since NF-κB also regulates the expression of a variety of proteins that inhibit apoptosis and promote cell survival/proliferation, it is also implicated in carcinogenesis (Karin et al., 2002).

    Item Type: Article
    Keywords: NF-κB; pathway; transcription factor; nuclear factor; proinflammatory cytokines; chemokines; adhesion molecules; cycloxygenase-2; inducible nitric oxide synthase; inducable enzymes;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7198
    Identification Number: https://doi.org/10.1242/jcs.02579
    Depositing User: Professor Paul Moynagh
    Date Deposited: 18 Jul 2016 15:58
    Journal or Publication Title: Journal of Cell Science
    Publisher: Company of Biologists
    Refereed: Yes
    URI:

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