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    Biomarkers for invasive aspergillosis: the challenges continue


    Johnson, Gemma and Ferrini, Arianna and Dolan, Stephen K. and Nolan, Tania and Agrawal, Samir and Doyle, Sean and Bustin, Stephen A. (2014) Biomarkers for invasive aspergillosis: the challenges continue. Biomarkers in Medicine, 8 (3). pp. 429-451. ISSN 1752-0363

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    Abstract

    The incidence of invasive aspergillosis (IA), an opportunistic infection in immunocompromised individuals, is rising, but its early diagnosis remains challenging and treatment options are limited. Hence there is an urgent need to improve existing diagnostic procedures as well as develop novel approaches. The clinical usefulness of galactomannan and β-d-glucan, widely used assays detecting cell-wall antigens of Aspergillus, is unclear and depends on clinicians’ awareness of their practical limitations. This leaves room for new methods that utilize genomic, proteomic and metabolomics approaches as well as novel detection procedures, for example pointof- care lateral-flow devices. Each of these strategies has its own limitations and it is likely that a combination of methods will be required to achieve optimal performance for the diagnosis of IA and subsequent appropriate patient management.

    Item Type: Article
    Additional Information: This is the postprint version of the published article, which is available at DOI 10.2217/bmm.13.129.
    Keywords: antifungal agents; Aspergillus; β-d-glucan; conidium; ELISA; fungal infection; galactomannan; immunosuppression; invasive aspergillosis; matrix-assisted laser desorption ionization-TOF; quantitative PCR; siderophore;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7389
    Identification Number: https://doi.org/10.2217/bmm.13.129
    Depositing User: Dr. Sean Doyle
    Date Deposited: 26 Aug 2016 14:48
    Journal or Publication Title: Biomarkers in Medicine
    Publisher: Future Medicine Ltd
    Refereed: Yes
    URI:

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