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    The N-end rule pathway regulates pathogen responses in plants


    de Marchi, Rémi and Sorel, Maud and Mooney, Brian and Fudal, Isabelle and Goslin, Kevin and Kwasniewska, Kamila and Ryan, Patrick T. and Pfalz, Marina and Kroymann, Juergen and Pollmann, Stephan and Feechan, Angela and Wellmer, Frank and Rivas, Susana and Graciet, Emanuelle (2016) The N-end rule pathway regulates pathogen responses in plants. Scientific Reports, 13 (6). p. 26020. ISSN 2045-2322

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    Abstract

    To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination of the plant immune response is known to require the activity of the ubiquitin/proteasome system, which controls the stability of proteins in eukaryotes. Here, we demonstrate that the N-end rule pathway, a subset of the ubiquitin/proteasome system, regulates the defense against a wide range of bacterial and fungal pathogens in the model plant Arabidopsis thaliana. We show that this pathway positively regulates the biosynthesis of plant-defense metabolites such as glucosinolates, as well as the biosynthesis and response to the phytohormone jasmonic acid, which plays a key role in plant immunity. Our results also suggest that the arginylation branch of the N-end rule pathway regulates the timing and amplitude of the defense program against the model pathogen Pseudomonas syringae AvrRpm1.

    Item Type: Article
    Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
    Keywords: N-end rule pathway; pathogen responses; plants; immune responses;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7423
    Identification Number: https://doi.org/10.1038/srep26020
    Depositing User: Emanuelle Graciet
    Date Deposited: 02 Sep 2016 08:31
    Journal or Publication Title: Scientific Reports
    Publisher: Nature Publishing Group
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Department of Agriculture, Food and the Marine, Laboratory of Excellence (France)
    URI:

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