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Roche, C., Boo, T.W., Walsh, Fiona and Crowley, B. (2008) Detection and molecular characterisation of plasmidic AmpC b-lactamases in Klebsiella pneumoniae isolates from a tertiary-care hospital in Dublin, Ireland. Clinical Microbiology and Infection, 14 (6). pp. 616-618. ISSN 1198-743X
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Abstract
This study determined the types of AmpC enzymes produced by Klebsiella pneumoniae isolates resistant to third-generation cephalosporins and the clonality of these isolates. The presence of AmpC enzymes was identified by cephalosporin-cloxacillin synergy tests. Genes encoding AmpC enzymes were characterised by PCR and sequencing. Pulsed-field gel electrophoresis (PFGE) was used to type the isolates. Fifteen K. pneumoniae isolates were positive for bla(AmpC), 13 were positive for bla(ACC-1) and two were positive for bla(DHA-1). Production of the DHA-1 enzyme was inducible. The ampR gene was identified upstream of the bla(DHA-1) gene. PFGE demonstrated the polyclonal origin of the isolates carrying bla(ACC-1).
| Item Type: | Article |
|---|---|
| Keywords: | ACC-1; AmpC b-lactamase; DHA-1; Klebsiella pneumoniae; resistance; typing; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 7478 |
| Identification Number: | 10.1111/j.1469-0691.2008.01998.x |
| Depositing User: | Fiona Walsh |
| Date Deposited: | 28 Sep 2016 15:29 |
| Journal or Publication Title: | Clinical Microbiology and Infection |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Funders: | Health Research Board (HRB) |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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