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    The in vitro effects of faropenem on lower respiratory tract pathogens isolated in the United Kingdom

    Walsh, Fiona and Amyes, A.K.B. and Amyes, Sebastian G.B. (2003) The in vitro effects of faropenem on lower respiratory tract pathogens isolated in the United Kingdom. International Journal of Antimicrobial Agents, 21 (2). pp. 581-584. ISSN 0924-8579

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    Faropenem is a new oral penem with a structure different from current β-lactams including carbapenems. The susceptibility of Streptococcuspneumoniae, Haemophilus influenzae and Moraxella catarrhalis to faropenem, a macrolide, a β-lactam, a β-lactam/β-lactamase inhibitor combination and two fluoroquinolones was investigated. S. pneumoniae was the most susceptible of the three species to faropenem. The MIC90s of faropenem against M. catarrhalis and H. influenzae were 0.5 and 1 mg/l, respectively. They were similar to amoxiclav (MIC 90s of 0.25 and 0.5 mg/l). The quinolones showed strong activity against H. influenzae. A cluster analysis of the activities of amoxycillin and faropenem demonstrated a direct relationship between the two antimicrobial agent's activities and resistance profiles against both S. pneumoniae and H. influenzae.

    Item Type: Article
    Keywords: Faropenem; Streptococcus pneumoniae; MIC;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7485
    Identification Number:
    Depositing User: Fiona Walsh
    Date Deposited: 04 Oct 2016 14:45
    Journal or Publication Title: International Journal of Antimicrobial Agents
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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