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    Thermal and physical stresses induce a short-term immune priming effect in Galleria mellonella larvae


    Browne, Niall and Surlis, Carla and Kavanagh, Kevin (2014) Thermal and physical stresses induce a short-term immune priming effect in Galleria mellonella larvae. Journal of Insect Physiology, 63. pp. 21-26. ISSN 0022-1910

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    Abstract

    Exposure of larvae of Galleria mellonella larvae to mild physical (i.e. shaking) or thermal stress for 24 h increased their ability to survive infection with Aspergillus fumigatus conidia however larvae stressed in a similar manner but incubated for 72 h prior to infection showed no elevation in their resistance to infection with A. fumigatus. Stressed larvae demonstrated an elevated haemocyte density 24 h after initiation of the stress event but this declined at 48 and 72 h. Larval proteins such as apolipophorin, arylophorin and prophenoloxidase demonstrated elevated expression at 24 h but not at 72 h. Larvae maintained at 37°C showed increased expression of a range of antimicrobial and immune-related proteins at 24 h but these decreased in expression thereafter. The results presented here indicate that G. mellonella larvae are capable of altering their immune response following exposure to mild thermal or physical stress to mount a response capable of counteracting microbial infection which reaches a peak 24 h after the initiation of the priming event and then declines by 72 h. A short-term immune priming effect may serve to prevent infection but maintaining an immune priming effect for longer periods may be metabolically costly and unnecessary while living within the colony of another insect.

    Item Type: Article
    Keywords: Insect; Galleria; Larvae; Immune priming; Immune response; Immunity;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7563
    Identification Number: https://doi.org/10.1016/j.jinsphys.2014.02.006
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 20 Oct 2016 15:40
    Journal or Publication Title: Journal of Insect Physiology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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