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    Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms


    Sullivan, Maeve and Folytn-Arfa Kia, Agnieszka and Long, Mark and Walsh, Maureen and Kavanagh, Kevin and McClean, Siobhan and Creaven, Bernadette S. (2014) Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms. Polyhedron, 67 (8). pp. 549-559. ISSN 0277-5387

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    Abstract

    A novel series of coumarin-4-carboxylate ligands (2a–2l), their Ag(I) complexes (3a–3l) together with a number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a–1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria.

    Item Type: Article
    Keywords: Pseudomonas aeruginosa; Biofilms; Silver complexes; Coumarin;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7571
    Identification Number: https://doi.org/10.1016/j.poly.2013.09.042
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 24 Oct 2016 16:51
    Journal or Publication Title: Polyhedron
    Publisher: Elsevier
    Refereed: Yes
    URI:

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