Sullivan, Maeve and Folytn-Arfa Kia, Agnieszka and Long, Mark and Walsh, Maureen and Kavanagh, Kevin and McClean, Siobhan and Creaven, Bernadette S.
(2014)
Isolation and characterisation of silver(I) complexes of substituted
coumarin-4-carboxylates which are effective against
Pseudomonas aeruginosa biofilms.
Polyhedron, 67 (8).
pp. 549-559.
ISSN 0277-5387
Abstract
A novel series of coumarin-4-carboxylate ligands (2a–2l), their Ag(I) complexes (3a–3l) together with a
number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The
ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation
of a methylated acid derivative. The esters (1a–1i) were synthesised by an aromatic electrophilic substitution
reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt.
The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin
ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction
of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes
were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically
or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and
Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater
than against the planktonic bacteria.
| Item Type: |
Article
|
| Keywords: |
Pseudomonas aeruginosa; Biofilms; Silver complexes; Coumarin; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7571 |
| Identification Number: |
https://doi.org/10.1016/j.poly.2013.09.042 |
| Depositing User: |
Dr. Kevin Kavanagh
|
| Date Deposited: |
24 Oct 2016 16:51 |
| Journal or Publication Title: |
Polyhedron |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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