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    Synthesis and X-ray crystal structure of [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione) and its effects on fungal and mammalian cells


    McCann, Malachy and Coyle, Barry and McKay, Sinead and McCormack, Paul and Kavanagh, Kevin and Devereux, Michael and McKee, Vickie and Kinsella, Paula and O'Connor, Robert and Clynes, Martin (2004) Synthesis and X-ray crystal structure of [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione) and its effects on fungal and mammalian cells. Biometals, 17 (6). pp. 635-645. ISSN 0966-0844

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    Abstract

    The Cu(II) and Ag(I) complexes, [Cu(phendio)3](ClO4)2⋅4H2O and [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione), are prepared in good yield by reacting phendio with the appropriate metal perchlorate salt. The X-ray crystal structure of the Ag(I) complex shows it to have a pseudo tetrahedral structure. `Metal-free' phendio and the Cu(II) and Ag(I) phendio complexes strongly inhibit the growth of the fungal pathogen Candida albicans, and are more active than their 1,10-phenanthroline analogues. The simple Ag(I) salts, AgCH3CO2, AgNO3 and AgClO4.H2O display superior anti-fungal properties compared to analogous simple Cu(II) and Mn(II) salts, suggesting that the nature of the metal ion strongly influences activity. Exposing C. albicans to `metal-free' phendio, simple Ag(I) salts and [Ag(phendio)2]ClO4 causes extensive, non-specific DNA cleavage. `Metal-free' phendio and [Ag(phendio)2]ClO4 induce gross distortions in fungal cell morphology and there is evidence for disruption of cell division. Both drugs also exhibit high anti-cancer activity when tested against cultured mammalian cells.

    Item Type: Article
    Keywords: 1,10-phenanthroline-5,6-dione; 1,10-phenanthroline; metal complex; silver(I); X-ray structure; Candida albicans; anti-fungal; cancer;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7577
    Identification Number: https://doi.org/10.1007/s10534-004-1229-5
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 26 Oct 2016 13:47
    Journal or Publication Title: Biometals
    Publisher: Springer Verlag
    Refereed: Yes
    Funders: Enterprise Ireland (EI)
    URI:

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