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    Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae


    Brennan, Marc and Thomas, David Y. and Whiteway, Malcolm and Kavanagh, Kevin (2002) Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunology and Medical Microbiology, 34 (2). pp. 153-157. ISSN 0928-8244

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    Abstract

    Candida albicans is a dimorphic human pathogen in which the yeast to hyphal switch may be an important factor in virulence in mammals. This pathogen has recently been shown to also kill insects such as the Greater Wax Moth Galleria mellonella when injected into the haemocoel of the insect larvae. We have investigated the effect of previously characterised C. albicans mutations that influence the yeast to hyphal transition on virulence in G. mellonella larvae. There is a good correlation between the virulence of these mutants in the insect host and the virulence measured through systemic infection of mice. Although the predominant cellular species detected in G. mellonella infections is the yeast form of C. albicans, mutations that influence the hyphal transition also reduce pathogenicity in the insect. The correlation with virulence measured in the mouse infection system suggests that Galleria may provide a convenient and inexpensive model for the in vivo screening of mutants of C. albicans.

    Item Type: Article
    Keywords: Immunity; Pathogenicity; Virulence testing; Candida; Galleria;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7595
    Identification Number: https://doi.org/10.1111/j.1574-695X.2002.tb00617.x
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 02 Nov 2016 16:43
    Journal or Publication Title: FEMS Immunology and Medical Microbiology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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